"All jokes aside, after a recent interview conducted with Dead Space Producer Rich Briggs, it's been made perfectly clear that there are no current plans for multiplayer support for the upcoming survival horror scarefest. Many gamers have been asking this question, including myself. One nameless Ishimura crew member versus their friends, as Necromorphs? It seems like it'd work in theory, and would be a welcome addition to a game that looks better and better with every bit of footage revealed. However, it's not merely for the reasons one would suspect-the game isn't fit for such a mode, it wouldn't work, etc."
Via TheGameReviews