As sumarized by Nintendo Everything:
"- Can execute hooks, uppercuts, Star Punches with Wii Remote/nunchuck
- Attempt to become champ of Minor, Major, World ranking organizations
- Fight against Glass Joe, Don Flamenco, King Hippo
- Play against 13 fighters in all
- Jabs with the Nunchuck Control Stick when punching
- Star Punch with C or A buttons
- Learn opponents attack patterns
- Game has a tutorial mode to guide players through basics
- Multiplayer mode included
- Giga Mac gauge built up in Head-to-Head mode by landing and dodging blows
- Can unleash serious damage when Giga Mac gauge is full
- Career, Exhibition, Head-to-Head modes confirmed
- Can be played with the Wii Remote held sideways"