Nintendo World Report writes: "I've never played, or even heard of the first Izuna game, but from what I've read, knowledge of the previous story is not necessary to enjoy the sequel. On the other hand, I'm thinking that Izuna 2 is an improvement on a system I would have benefitted from getting used to. This is a dungeon-crawler, a dungeon-crawler that, while actually pretty fun, is also painfully unforgiving and brutally difficult. You've really got to want to play it, and if this niche genre is not your style, Izuna 2 is not the game to ease you into it.
Izuna is a wisecracking, food-loving, skintight-garb-wearing ninja with cat ear goggles and enormous breasts. I'm usually not adverse to female characters with ridiculous racks (Tomb Raider: Anniversary, Soulcalibur IV, and Dead or Alive Xtreme Beach Volleyball are all on my shelf), but when the main character is a very stylized anime teenager, it looks weird. It looks weirder when almost every female NPC in the game is similarly endowed, and the eyebrows really start to raise when the number of in-jokes involving those most mammarian of traits reaches nauseating numbers."